Silencing of GPR81 dramatically reduced tumor cell survival in lactate-supplemented, low-glucose conditions, suggesting its essential role in lactate utilization under nutrient stress
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Because ascorbate is abundant in most tissues, particularly in the brain, indirect information about the short-lived ROS formed in biological systems can be obtained from the quantitative evaluation of the level of ascorbyl radicals, considered terminal radicals of the cascade of radical reactions occurring in biological systems
That sudden return of circulation, in effect, a shock to the system, is known to cause a surge of inflammation and oxidative stress, that can actually make things worse
